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Wednesday, March 23, 2011

By causing the mutation of one specific gene, researchers have produced mice with two frequently encountered behavioral traits of persons diagnosed with autism. Autism commonly affects the ability to interact socially and is associated with repetitive behavior. The finding was reported in the March 20 online edition of Nature.

Using mice, researchers at the Massachusetts Institute of Technology (MIT) and Duke University mutated one of the genes associated with autism, known as shank3, a gene that controls the production of the shank3 protein present in the brain. Mice that were given this mutation exhibited repetitive behavior and avoided social interactions with the mice around them.

According to MIT Professor Guoping Feng: “Our study demonstrated that Shank3 mutation in mice lead to defects in neuron-neuron communications.”

Shank3 protein are found in synapses within the brain. Synapses allow brain cells (called neurons) to communicate with each other. The mutation in the mouse gene interfered with this communication, apparently producing the subsequent autism-like traits. Researchers believe their work demonstrates the important role of shank3 in the functioning of brain circuits that determine behavior.

While hundreds of genes have been linked to autism in human patients, only a small percentage have been linked to shank3. Professor Feng hypothesizes that disruptions of other genes that act on the production of brain proteins affecting synaptic communication may also be related to autistic behavior. If this disruption is real, Feng claims that treatments could be developed to correct synaptic function for any defective synaptic protein in an autistic patient.

Feng continued; “These findings and the mouse model now allow us to figure out the precise neural circuit defects responsible for these abnormal behaviours, which could lead to novel strategies and targets for developing treatment.”

About one in 110 children in the U.S., and at least one in 100 in UK, have been diagnosed with an autism spectrum disorder, for which there is currently no effective cure.

Friday, April 3, 2009

General Motors (GM) and Chrysler will receive bridge loans from the government of Canada and the provincial government of Ontario, however no more will be forthcoming from either Canadian or US governments unless the companies can reinvent themselves.

“This is a regrettable but necessary step to protect the Canadian economy. We are doing this on the assumption that we obviously cannot afford either in the United States or Canada a catastrophic short-term collapse.” said Stephen Harper, Prime Minister of Canada.

“We cannot, we must not, and we will not let our auto industry simply vanish. This industry is, like no other, an emblem of the American spirit; a once and future symbol of America’s success,” said Barack Obama, President of the United States. “These companies – and this industry – must ultimately stand on their own, not as wards of the state.”File:Sinsheim quer.jpg

Chrysler will receive CA$1 billion and may in fact be eligible for as much as CA$4 billion. If Chrysler succeeds in the next 30 days with a restructuring plan it would be eligible for a US$6 billion loan. A part of Chrysler’s restructuring plan must include a partnership with Fiat within 30 days to appease the US administration. Fiat is a supplier of smaller fuel-efficient vehicles, and the merger will help Chrysler to be viable in the North American market. A Chrysler court bankruptcy would inevitably lead to it being sold off.

As a part of Chrysler’s restructuring plans, Tom LaSorda, the president of Chrysler announced that Canadian operations would fold if it does not receive both the US commitment of $2.3 billion of aid and a new Canadian Auto Workers CAW contract to reduce all-in costs by CA$19 per hour. As a result of this announcement Chrysler’s auto sales volume in Canada dropped 23% compared to March of 2008.

GM has until the end of May to restructure its company to receive up to CA$7.5 billion. As part of the companies restructuring, General Motor’s chief executive Rick Wagoner was replaced Sunday with Fritz Henderson, the current chief operating officer. Henderson spoke out on Tuesday that GM has submitted a restructuring plan which would close five plants, and this may be increased to meet the requirements for financial aid. He is in full compliance with Obama’s auto task force to seek bankruptcy if GM cannot negotiate with their unions, bondholders and others.

GM recently brought forward the “GM Total Confidence” program providing consumer purchase protection for customers who lose their job for economic reasons within the first two years from purchase. As a result of Chrysler’s restructuring announcement in Canada, GM’s Canadian vehicle sales volume fell only 17.3% compared to 2008, an increase from the previous month.

GM must reduce some of its legacy costs which include its pensions and union health care costs. A part of GM’s ailments arose from investing in supplying truck and SUVs during an economy of high gas prices when consumers were demanding fuel efficient vehicles.

Tony Clement, Canada’s Minister of Industry, is hoping that the CAW will support the restructuring process and re-negotiate their agreement. Whereas a United Auto Workers negotiator has said, “I don’t see how the UAW will do anything until they see what the bondholders will give up.”

The Obama administration is looking toward bankruptcy proceedings for the automakers, “as a mechanism to help them restructure quickly and emerge stronger. [It will] quickly clear away old debts that are weighing them down. What we are asking is difficult. It will require hard choices by companies. It will require unions and workers who have already made painful concessions to make even more. It will require creditors to recognise that they cannot hold out for the prospect of endless government bailouts.” said Obama.

The auto parts suppliers and IT software exporters in India have already been affected by the declining auto sales. GM and Chrysler software contracts provide US$300 to 350 million a year to vendors in India. As well these two major automakers usually award US$1 billion contracts to auto parts suppliers. “We are worried and closely watching the developments in the US to gauge the impact. The decline in auto sales in the US has already hit the order books of Indian suppliers,” said a Delhi auto parts supplier.

“Going forward, the industry will undoubtedly be smaller, but if our efforts are successful it will be viable and it will support good jobs for Canadians,” said Clements.

Betty Sutton, Ohio’s Congresswoman put forward the CARS act which provides a US$3,000 to 5,000 incentive for those who trade in their vehicle for a fuel-efficient car. “It clearly stimulates the economy, and it gets the consumer into the showroom and gets them buying again. But importantly — and this is what I particularly like about it — it really helps the environment quite a bit in two respects.” said William Clay Ford Jr., executive chairman of Ford Motor Co.

Ford Motor Company has not come forward with requests for assistance.

Since December GM and Chrysler have received US$17.4 billion government loans.

Tuesday, March 28, 2006

Buffalo, New York —The proposed Elmwood Village Hotel got the final approval it needed from the city of Buffalo’s Planning Board this morning.

In a unanimous vote, the Board approved most of the design and site plan of the hotel.

The Elmwood Village Hotel is a proposed hotel by Savarino Construction Services Corporation and is designed by architect Karl Frizlen of the Frizlen Group. It is to be placed on the corner of Elmwood and Forest Avenues in Buffalo and will require the demolition of at least five properties (1109-1121 Elmwood).

Despite the fact that today’s meeting was not a “public hearing”, several citizens lashed out at the Board after the approval.

“Thanks for destroying Buffalo,” said one man.

“[I am] disgusted. Because they did not allow the community to speak, it is the bastardization of the concepts of justice and democracy, and that’s what happened [today],” said Clarence Carnahan, a local business owner and concerned citizen, to Wikinews. He also referred to some board members as “immoral pigs.”

“[I feel] frustration because no one could speak. I was going to address the displacement of all the shops that are there and that they should be grand-fathered into the new space. We did not get to say that. [I am disappointed] that they are endorsing this enormous monstrosity.” said Nancy Pollina, co-owner of Don Apparel with Patty Morris at 1119 Elmwood.

Although the Board approved the hotel proposal, Savarino Construction must still go before the board to approve things such as signage and lighting. The Planning Board meets again on April 11, 2006 at 8:00a.m., but it is unknown if the hotel proposal will be on the agenda.

Pano Georgiadis, owner of Pano’s Restaurant at 1081 Elmwood and owner of 605 Forest Avenue in Buffalo, threatened to sue Savarino Construction at a public meeting on March 15, 2006 saying, “if you try to get a variance to change the code, I will sue you. This is my home, number one. If you go against city code, and you try to do the most rooms with a minimal amount of parking, again, I will sue you.”

Today, Georgiadis confirmed to Wikinews that he is “definitely” suing, but that his “situation is different” as compared to others looking into legal action. “This is my property. They did it [changed the code] without my approval.”

Last week, the Common Council voted and approved the rezoning of all five properties including 605 Forest.

Some are also considering taking the case to the New York State Supreme Court to “seek an injunction”and would go “pro se, meaning I am going to present the case myself,” said Carnahan.

Despite the approvals by the Common Council and Planning Board, organizers schedulaed another protest for Saturday April 1, 2006 at 2:00p.m. on the proposed site at Forest and Elmwood.

“We are not going to go down without a fight. We are going to go kicking and screaming,” said Pollina.

Saturday, September 27, 2008

On October 14, 2008, Canadians will be heading to the polls for the federal election. Liberal candidate Andrew Lang is standing for election in the riding of Toronto—Danforth.

Raised with Liberal values, Andrew attended his first Liberal rally at age 6. He has worked 18 elections since that introduction to the political sphere, but this is his first time as a candidate. A University of Toronto graduate (and player for the Varsity Blues), his career highlights include managing Bill Graham’s constituency office. (A now-retired MP, Graham’s career included serving as Minister of National Defence and Minister of Foreign Affairs, as well as interim Leader of the Liberals and Leader of the Opposition.) He is currently with the Ontario Chiropractic Association.

Wikinews contacted Andrew, to talk about the issues facing Canadians, and what they and their party would do to address them. Wikinews is in the process of contacting every candidate, in every riding across the country, no matter their political stripe. All interviews are conducted over e-mail, and interviews are published unedited, allowing candidates to impart their full message to our readers, uninterrupted.

The incumbent in this riding is National Democratic Party (NDP) leader Jack Layton. Other than Lang, trying for the riding are Sharon Howarth (Green), and Christina Perreault (Conservative). Minor party candidates Marie Crawford (Animal Alliance Environment Voters Party of Canada), Marcell Rodden (Marxist-Leninist), and Bahman Yazdanfar (Canadian Action Party) are also running, as is independent John Richardson. The riding has existed federally since 1979, and has the seat has been occupied by Bob Rae (NDP, 1979–1982), Lynn McDonald (NDP, 1982–1988), Dennis Mills (Liberal, 1988–2004), and Layton (NDP, 2004 to present).

For more information, visit the campaign’s official website, listed below.

Sunday, January 16, 2022

United Kingdom-based pharmaceutical giant GlaxoSmithKline (GSK) confirmed January 15 it had rejected three “unsolicited, conditional and non-binding proposals” by Unilever to acquire its Consumer Healthcare division, including one bid of GBP50 billion in value made on December 20, believing Unilever “fundamentally undervalued” the business and its potential.

News that Unilever attempted to buy GSK Consumer Healthcare for 50 billion pounds, split between GBP41.7 billion in cash and 8.3 billion in Unilever shares, was first reported by The Sunday Times, and subsequently confirmed by both companies. Had the latest acquisition offer gone through, it would have been the largest deal since the beginning of the Covid-19 pandemic, and one of the biggest ever among companies listed on the London Stock Exchange.

A deal would likely mean integrating the GSK division into Unilever’s own beauty and personal care business, which has seen profit margins struggle under Covid-19 lockdowns and higher costs for plastics and petrochemicals.

A brief response on the Unilever website confirmed it “had approached GSK and Pfizer about a potential acquisition”, and adds GSK Consumer Healthcare “would be a strong strategic fit” as the company looks to rework its portfolio. GSK indicated the proposals were “carefully evaluated” by its board of directors, but unanimously rejected under the conclusion they “were not in the best interests of GSK shareholders” and “failed to reflect the intrinsic value of the business and its potential”.

The Sunday Times have indicated the latest deal did not include an acquisition premium or recognition of corporate synergies; the joint venture between GSK and healthcare firm Pfizer, which holds a minority stake in the company, was initially projected to generate GBP500 million in cost savings by this year and realise “substantial cost synergies”. The BBC’s business editor Simon Jack wrote that a standard takeover premium would be about 30%, but could be reduced over the GBP10 billion in debt GSK was predicted to “leave on the books”, of the GBP22 billion net debt GSK reported for Q3 2021.

The deals were assessed by the Board respective of a proposed demerger of GSK Consumer Health into a separate PLC in the middle of this year. Jack wrote GSK “always” had “an open mind to a trade sale to another party if the price was right.” Unilever did not take into account the standard takeover premium, the value of cost savings and Board confidence Consumer Health could deliver “superior organic sales growth” of between four and six per cent in the medium term. This was despite valuations of about GBP50 billion by Goldman Sachs and Barclays analysts, and a lower GBP45 billion valuation by Jeffries Group.

There are no current talks between Unilever and either Pfizer or GSK, and the Unilever statement reads: “There can be no certainty that any agreement will be reached.” Under CEO Alan Jope, Unilever has focused its investments and marketing on brands which “communicate a strong environmental or social purpose” by streamlining its holdings in items like beauty products and tea. Jope previously said Unilever would concentrate on smaller takeovers in industries like luxury beauty and wellness.

However, Russ Mould, investment director at AJ Bell, told the BBC this would be a “high risk deal” at a time investors are cautious about GSK’s performance, but also a time of rising inflation he says encourages “consumer goods with loyal customers”. Mould added despite strong cashflow, Unilever had recently missed targets on sales and profit margins, putting pressure on the CEO.

Pressure by activist shareholders Elliott Management Corporation and Bluebell Capital Partners have also mounted against GSK CEO Emma Walmsley over the unit’s failure to develop a Covid-19 vaccine and Walmsley’s own lack of scientific experience. GSK has been involved in the ongoing development of a Covid-19 vaccine with French biopharmaceutical company Sanofi, and announced preliminary results from Phase 3 trials last month.

In 2018, Unilever bought several consumer nutritional products from GSK, including its flagship product Horlicks, and merged its Indian subsidiary, Hindustan Unilever, with GSK Consumer Healthcare India.

Tuesday, May 29, 2007

File:Bathurst location map in New South Wales.PNG

Police searching for the remains of missing Bathurst woman Janine Vaughan have discovered bones which they claim may belong to the missing woman. Ms Vaughan disappeared after being seen getting into a red car with a male after being a Bathurst pub on December 7, 2001.

On Sunday, police began a fresh search for the missing woman’s remains after they received new information. On Monday at approximately 3:00 p.m. AEST police discovered bones during a ground sweep of an area off Montavella Road, Gormans Hill adjacent to the Macquarie River. Forensic services police were bought in several hours later, but initial tests proved inconclusive.

Police were guarding the site overnight and forensic officers are expected to conduct further tests today.

Police also search bushland near a creek at Yetholme, 15 km East of Bathurst on Monday using two specialist cadaver dogs on loan from Queensland Police.

Police have revealed that the search has prompted several members of the local community to call the police’s Crime Stoppers hotline with information. Chief Superintendent Mark Holahan said “It’s a cross-section of information. Some of it will probably lead us to some new lines of inquiry, and some of it will help us to reaffirm some of those things we already know.”

The detective who led the initial investigation into Ms Vaughan’s disappearance for several days continues to be a person of interest to police in the case. The detective, Brad Hosemans, is also a former deputy mayor of the city. Mr Hosemans, who has since left the police force, has denied any involvement.

Chief Supt. Holahan said the former detective was only one of a number of persons of interest in the case.

The Police Integrity Commission has investigated the initial handling of the case but is yet to hand down a finding.